N. D. Zelinsky Institute of Organic Chemistry
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Last Update:
January 21, 2006

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founded in 1959 by Professor Nikolay K. Kochetkov


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Chemical Synthesis

 

  Chemical synthesis of carbohydrates of biological significance (mono-, oligo- and poly-saccharides and neoglycoconjugates on their basis)

Synthesis of various neoglycoconjugates for glycotargeting
For more detailed information please contact Dr. Leonid Kononov
(
kononov@ioc.ac.ru, leonid.kononov@gmail.com, kononov@newmail.ru).

Synthesis of oligosaccharides related to the lipoarabinomannan of Mycobacterium tuberculosis and neoglycoconjugates thereof
For more detailed information please contact Dr. Leonid Kononov
(
kononov@ioc.ac.ru, leonid.kononov@gmail.com, kononov@newmail.ru).

Synthesis of lipooligosaccharides related to Rizobium nodulation factors
For more detailed information please contact Dr. Vladimir Torgov (torgov@ioc.ac.ru)
or Alexander Zinin (
zinin@ioc.ac.ru).

Synthesis of linear and dendritic manno-oligosaccharides
For more detailed information please contact Prof. Leon Backinowsky (leon@ioc.ac.ru).

 

Chemical synthesis of glycosyl phosphates and polyprenyl phosphate derivatives for studies of biosynthesis of bacterial polysaccharides

Sialic acid glycosyl phosphates
For more detailed information please contact Dr. Leonid Kononov
(
kononov@ioc.ac.ru, leonid.kononov@gmail.com, kononov@newmail.ru).

Sugar nucleotide phosphate derivatives
For more detailed information please contact Dr. Leonid Kononov
(
kononov@ioc.ac.ru, leonid.kononov@gmail.com, kononov@newmail.ru).

Polyprenyl and dolichyl phosphate derivatives
For more detailed information please contact Dr. Sergey Maltsev (smalru@yahoo.com).

 

Supramolecular carbohydrate chemistry
For more detailed information please contact Dr. Leonid Kononov
(
kononov@ioc.ac.ru, leonid.kononov@gmail.com, kononov@newmail.ru).

 
     

Main Research Areas of the Laboratory:

Structure Determination

Biosynthetic Studies

The main field of our research in this area is elucidation of structures of bacterial polysaccharides and lipopolysaccharides aiming at better understanding of structure-function relationships and classification of important bacteria. Learn more...

Research on enzymes involved in biosynthesis of bacterial polysaccharides has long been one of the main interests of the laboratory. The study of the substrate specificity of glycosyl transferases  and chemical-enzymatic synthesis of Salmonella polysaccharides are just a few examples. Learn more...

Chemical Synthesis

Physico-Chemical Studies

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Along with traditional uses of physico-chemical methods such as NMR spectroscopy and mass spectrometry for characterization of "isolated" carbohydrate molecules and study of their conformations, new approaches are being developed for the study of intermolecular interactions of carbohydrate derivatives in solutions. Learn more...

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