Structure Determination

Biosynthetic Studies

The laboratory is well known for extensive research in the area of elucidation of structures of bacterial polysaccharides and lipopolysaccharides aiming at better understanding of structure-function relationships and classification of important bacteria. Several new methods for selective cleavage of inter-saccharidic glycoside bonds have been developed at the laboratory. Learn more...

Research on enzymes involved in biosynthesis of bacterial polysaccharides has long been one of the main interests of the laboratory. The study of the substrate specificity of glycosyl transferases  and chemical-enzymatic synthesis of Salmonella polysaccharides are just a few examples. Learn more...

Chemical Synthesis

Physico-Chemical Studies

Chemical synthesis of complex carbohydrates and other compounds involved in biosynthesis of carbohydrates has been in the focus of the laboratory activities from the very beginning. The interests have been ranging from the chemical synthesis of mono-, oligo- and polysaccharides and their derivatives to the use of carbohydrates as the source of chirality in the synthesis of natural compounds such as macrocyclic antibiotics.  Quite a few new synthetic methods originated from the laboratory. Learn more...

Conformational analysis (both theoretical and experimental) of carbohydrates and glycoconjugates has been whithin the interests of the laboratory for many years. This research was performed in cooperation with the NMR Laboratory at N. D. Zelinsky Institute of Organic Chemistry.